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KMID : 0613320030090010077
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Journal of the Korean Bone and Joint Tumor Soceity
2003 Volume.9 No. 1 p.77 ~ p.83
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Expression of PTEN, Tumor Suppressor Protein, in Aggressive Fibromastosis
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Kim Jung-Ryul
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Abstract
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Aggressive fibromatosis is a rare soft tissue tumor with locally invasive and infiltrative characteristics. The mechanism of this invasive nature was not reported until now. Mutations or reduction of PTEN., tumor suppressor gene, in cancer tissues, have been found to be associated with invasiveness and metastatic properties of cancer cells. To know the pattern of expression of PTEN in aggressive fibromatosis , we analysed the expression of PTEN with immunohistochemical stain and immunoblotting. PTEN was homogeneously expressed in the normal musculoaponeurotic tissues, but absent or very faint in tissues of patients with aggressive fibromatosis as evidenced by western blot analysis and immunohistochemical examinations. Although the meaning of decreased PTEN expression in aggressive fibromatosis is not certain, it might be involved in the growth of the aggressive fibromatosis, and associated with phenotype of aggressive fibromatosis.
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KEYWORD
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Aggressive fibromatosis, Invasiveness
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